BostonGene Announces Scientific Collaboration with the Vaccine and Immunotherapy Center at Massachusetts General Hospital

Sophisticated Data Analytics to Validate Tumor Molecular Profiles in Cancer Patients

WALTHAM, MA – January 14, 2020 – BostonGene Corporation (BostonGene), a biomedical software company, today announced its collaboration with the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital.

BostonGene performs a computational analysis of a patient’s genomics and transcriptomics data from solid tumors including Lung Cancer and Head and Neck Cancer. In parallel, MGH VIC team conducts mass cytometry analysis of tissue of same patients. A correlation analysis is then employed to demonstrate the power of the computational algorithms in the assessment of the intratumoral cellular composition including stromal and immune components. The results of this collaboration highlight the powerful advantage of NGS data analysis in comparison to conventional techniques to more fully characterize the tumor.

Using small amounts of tissue, BostonGene provides an accurate, patient tailored report for physicians. The report includes a visually-appealing and self-explanatory tumor schematics, called MF Portrait™, depicting tumor activity, tumor cellular composition, activity of immune-microenvironment and other tumor-associated processes.

“Our collaboration with BostonGene is aimed at understanding the pathogenesis of each person’s cancer and ultimately having a positive impact on patient care by enabling personalized cancer treatments,” said Mark Poznansky, MD, PhD, at Massachusetts General Hospital.

“BostonGene provides the solution necessary for oncologists to evaluate NGS data in combination with all relevant clinical knowledge to determine the best personalized care for the individual patient,” said Andrew Feinberg, President and CEO of BostonGene. “We are excited to collaborate with VIC at MGH to demonstrate how our unique solution for tailored treatment options improves outcomes for cancer patients.”

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contacts:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene and Weill Cornell Medicine Reveal Results from Cancer Microenvironment Study

ORLANDO, FL , December 9, 2019 – BostonGene Corporation (BostonGene), a Boston-based biomedical software company, presented results of its recent cancer microenvironment study during the 61st American Society of Hematology Annual Meeting and Exposition held on December 7-10, 2019. The research study examined the role of the tumor microenvironment of Diffuse Large B-Cell Lymphoma (DLBCL).

The study, conducted as part of BostonGene’s collaboration with Weill Cornell Medicine, combined whole exome and transcriptome analyses from an integrated cohort of 3,026 DLBCL patients. The cohort includes publically available data as well as prospective patients.

The study revealed that a new classification based on the tumor microenvironment is associated with clinical outcomes independently of existing molecular subtypes. Computationally predicted results demonstrated a strong correlation with response therapy obtained in murine DLBCL models for subtypes based on stromal, immune and malignant composition.

“Improving treatment outcomes for individual DLBCL patients by integrated analysis of large-scale next-generation sequencing (NGS) data including somatic variants and gene expression changes in the tumor and the tumor microenvironment is our top priority,” said Leandro Cerchietti, M.D., Associate Professor of Medicine and a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine. “These promising findings bring us one step closer to achieving that goal.”

“We are proud to collaborate with Weill Cornell Medicine to provide advanced computational analytics for the integration of big data sets generated for each patient,” said Andrew Feinberg, President and CEO of BostonGene. “We look forward to continuing our collaboration to further identify the best treatment options for cancer patients.”

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contact:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene to Present Multiple Abstracts at the 2019 American Society of Hematology (ASH) Annual Meeting

WALTHAM, MA, November 21, 2019 — BostonGene Corporation (BostonGene), a Boston-based biomedical software company, today announced that as a result of its collaborations, multiple abstracts have been accepted for presentation at the 61st American Society of Hematology Annual Meeting and Exposition to be held December 7-10, 2019 in Orlando, Florida. In addition, BostonGene will exhibit at booth #152 in Hall B.

The presentations will provide results demonstrating the role of the tumor microenvironment in cancer classification and treatment outcomes. By combing whole exome and transcriptome sequencing analysis, the significance of stromal and immune compartments of microenvironment in therapeutically relevant categories of Mantle Cell Lymphomas and Diffuse Large B-Cell Lymphoma (DLBCL) is identified.

POSTER PRESENTATION

Sunday, December 8, 2019: 6:00 PM – 8:00 PM in Hall B, Level 2

ORAL PRESENTATION

Monday, December 9, 2019: 10:45 AM in Tangerine 2 (WF2), Level 2

Additional information on abstracts for ASH Annual Meeting can found here: http://www.hematology.org/Annual-Meeting/.

“We are excited to share our success as a strategic collaborator with two of the leading cancer centers in the world at this year’s ASH event. We look forward to showcasing our innovative platform that will ultimately impact and improve cancer patients’ chances for survival,” said Andrew Feinberg, President & CEO at BostonGene.

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contact:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com


	

BostonGene Announces Cancer Research Collaboration with Washington University in St. Louis

Integration of Genomic, Transcriptomic, Proteomic and Imaging Analysis aimed at Understanding Cancer Progression and Tumor Microenvironment Involvement

WALTHAM, MA – October 8, 2019 – BostonGene Corporation (BostonGene), a Boston, Mass-based biomedical software company, today announced a master agreement with Washington University School of Medicine in St. Louis to collaborate on multiple research projects.

BostonGene’s solution will provide Washington University oncologists at Siteman Cancer Center with detailed analysis, interpretation and visualization of big data obtained from cancer patient’s genomic, transcriptomic, proteomic and imaging tests. The solution identifies all significant somatic alterations, evaluates protein expression, computes tumor clonality, tumor heterogeneity, tumor microenvironment cell type composition, hereditary predisposition, viral infestation, pharmacogenomics and predicts neoantigens for personalized vaccine development among other molecular features. BostonGene generates a visually-appealing and self-explanatory tumor schematics, called MF Portrait™, elegantly depicting tumor activity, tumor cellular composition, activity of immune-microenvironment and other tumor-associated processes.

“We’re collaborating with BostonGene to evaluate how its technology can help us identify the best treatments for patients based on the underlying characteristics of their cancers, with the goal of increasing survival. The company’s analytics and integration of scientific and clinical knowledge is aimed at complementing and empowering the precision medicine approach for individual cancer patients,” said Todd Fehniger, MD/PhD, a Washington University medical oncologist who treats patients at Siteman Cancer Center.

“BostonGene’s mission is to provide every patient with the highest probability of survival by selecting optimal cancer treatments using sophisticated analytics and integration of scientific and clinical knowledge,” said Andrew Feinberg, President and CEO of BostonGene. “With our collaboration with Washington University we are transforming cancer care from treating a diagnosis to treating the patient.”

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contact:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene Announces Agreement with The University of Texas MD Anderson Cancer Center

Multiple Research Projects Analyze Genomic Data Sets to Understand Disease Progression and Therapeutic Resistance

WALTHAM, MA – September 10, 2019 – BostonGene Corporation (BostonGene), a biomedical software company, today announced an agreement with The University of Texas MD Anderson Cancer Center to work together on multiple research projects to better understand the impact of genome data sets on therapeutic resistance.

Identifying composition and activity of nonmalignant cells within the immune microenvironment of the tumor is becoming critical in determining clinical outcomes, including survival, progression, and therapy response. BostonGene’s solution integrates next-generation sequencing (NGS) obtained from a patient’s tumor with a reference cohort of data from patients with similar diagnosis, simultaneously analyzing tumor and tumor microenvironment activity.

BostonGene delivers oncologist-friendly schematics called MF Portrait™ that depict tumor cellular composition, immune- and stromal microenvironment and activity of tumor-related processes. For one project, BostonGene will assist MD Anderson’s Dr. Michael Wang and his mantle cell lymphoma team by identifying somatic variants, gene expression changes, and tumor microenvironment composition associated with disease progression and other outcomes.

“BostonGene is transforming and personalizing medicine, from treating a diagnosis to treating the person. By partnering with MD Anderson we are closer to understanding why immuno- and targeted therapies are effective for some and not for other patients. Together we are using the BostonGene product to help determine the best treatment for an individual patient,” said Andrew Feinberg, President and CEO of BostonGene.

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contact:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

BostonGene Announces Partnership with National Institutes of Health

Precision Medicine Studies Underway to Enable Dynamic Monitoring of Disease Progression and Response to Treatment

WALTHAM, MA – July 23, 2019 – BostonGene Corporation (BostonGene), a biomedical software company, today announced its partnership with the National Institutes of Health (NIH) including the National Cancer Institute (NCI) and the National Institute of Allergy and Infectious Diseases (NIAID).

BostonGene’s solution will provide NCI and NIAID with an interpretation and visualization of a patient’s next-generation sequencing (NGS) information within the landscape of a patient’s genetic and genomic data at a desired level of complexity. The solution will identify all significant somatic alterations, evaluation of protein expression, estimation of tumor heterogeneity, prediction of neoantigens, tumor clonality, hereditary predisposition, viral infestation and pharmacogenomics among other molecular features. BostonGene generates a visually-appealing and self-explanatory tumor schematics, called MF Portrait™, depicting tumor activity, tumor cellular composition, activity of immune-microenvironment and other tumor-associated processes.

“Immuno- and targeted therapies are the most promising and rapidly developing treatments for cancer. BostonGene is thrilled to be partnering with NIH to provide sophisticated data analytics to produce viable treatment options personalized for each patient. Our mission is to treat the patient, not treat the diagnosis,” said Andrew Feinberg, President and CEO of BostonGene.

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Media Contact:
BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

Biomedical Software Startup BostonGene Secures $50M in Series A Financing from NEC

Proceeds to Support Scaling and Advancement of Precision Medicine Computing Platform for Cancer Treatment

Tokyo, April 25, 2019 and Boston, April 24, 2019NEC Corporation (NEC; TSE: 6701) and BostonGene Corporation (BostonGene), a Boston, Mass-based biomedical software company, today announced a US$50M series A strategic investment in BostonGene by NEC.

BostonGene, a pioneer in the use of biomedical software for advanced patient analysis, has discovered, developed, and patented a holistic approach to cancer treatment by defining the optimal therapy combination for individual patients, with a particular focus on immuno- and targeted therapies. BostonGene’s solution includes:

  • Genome and transcriptome sequencing methods to create a patient’s molecular profile.
  • Algorithms that estimate the immune fitness and cancer characteristics of a patient.
  • A continuously updated expert-curated and Artificial Intelligence (AI)-driven database of cancer research and clinical information.
  • Cloud-native software that delivers a patient-prioritized list of best treatment options based on comprehensive data analysis of the tumor and its microenvironment.

Founded in 2015, BostonGene has evaluated its solution utilizing extensive data in close collaboration with many leading cancer centers across the U.S., and has a robust intellectual property portfolio.

The funding will allow BostonGene to accelerate its long-term strategy, enable the expansion of the company’s development efforts, advance its collaboration programs, and support the growth of its talented and diverse team.

“As demonstrated by its remarkable growth and early widespread adoption, BostonGene is leading the precision medicine market in the innovation and development of a mission-critical computing platform,” said Osamu Fujikawa, Senior Vice President and Head of the Business Innovation Unit at NEC Corporation. “NEC and BostonGene share a common vision of the immense potential of an AI-driven approach to cancer immunotherapy. Leveraging the strengths of both companies we will be able to improve the survival rate and quality of life for cancer patients.”

“Transforming and personalizing medicine, from treating a diagnosis to treating the person, is becoming a reality with BostonGene’s unique breakthrough platform. Our early successes validate the market need and the potential of our solution to truly transform cancer treatment and dramatically improve patients’ chances for survival and quality of life. An investment of this magnitude will support our vision, mission and strategy, as well as the formation of synergies with the NEC Health Tech business to create meaningful new opportunities,” said Andrew Feinberg, President and CEO of BostonGene.

About NEC Corporation
NEC Corporation is a leader in the integration of IT and network technologies that benefit businesses and people around the world. The NEC Group globally provides “Solutions for Society” that promote the safety, security, efficiency and equality of society. Under the company’s corporate message of “Orchestrating a brighter world,” NEC aims to help solve a wide range of challenging issues and to create new social value for the changing world of tomorrow. For more information, visit NEC at https://www.nec.com.

About BostonGene Corporation
BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient’s individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGene’s mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

NEC is a registered trademark of NEC Corporation. All Rights Reserved. Other product or service marks mentioned herein are the trademarks of their respective owners. ©2019 NEC Corporation.

Media Contacts:

BostonGene
Erin O’Reilly
+1-781-366-7049
Erin.Oreilly@BostonGene.com

NEC Corporation
Joseph Jasper
Corporate Communications Division
j-jasper(at)ax.jp.nec.com